We recently revealed a prominent role for the Notch pathway in differentiation of T helper cells into cytokine producing effector cells (Amsen et al. Cell 117, 515; Amsen et al., Immunity 27, 89). Notch is an evolutionarily conserved cell surface receptor with many functions both in healthy tissues and in disease (notably cancer). Notch controls transcription using a seemingly simple linear pathway. However, the great diversity of roles for Notch in metazoan biology suggests the existence of unknown layers of control.
Using a combination of proteomics, genomics, molecular biology and immunology, we aim to identify protein partners for Notch and study how these control the specificity of the response to this factor. Results from this analysis will enhance our understanding of T cell biology as well as of the development of cancer.
We are looking for an ambitious graduate student with a background in Biochemistry, Molecular Biology or Immunology. Funding will be provided for 4 years. Students are enrolled in the PhD program at the University of Amsterdam. Interested candidates should send a cover letter describing your professional interests as well as career goals, a C.V and the names and contact information of at least two references to
Dr. Derk Amsen,
Department of Cell Biology,
Academic Medical Center
Meibergdreef15
1105AZ Amsterdam, The Netherlands
D.amsen@amc.nl
For further information check our website: http://www.amc.nl/index.cfm?pid=3680
January
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